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Acetaminophen is metabolized while in the liver through cytochrome P450 microsomal enzyme. About 8085% in the acetaminophen in the human body is conjugated principally with glucuronic acid and also to a lesser extent with sulfuric acid and cysteine. Just after hepatic conjugation, ninety to 100% on the drug is recovered from the urine with in the v

Physical dependence on a prescribed medication does not signify dependancy. Physical dependence includes the occurrence of the withdrawal syndrome when You can find sudden reduction or cessation in drug use or if an opiate antagonist is administered. Actual physical dependence may be detected immediately after a few days of opioid therapy. Nonethel